Portal de Periódicos da CAPES

A mild and selective method for N-dealkylation of tertiary amines

2004; Elsevier BV; Volume: 45; Issue: 43 Linguagem: Inglês

10.1016/j.tetlet.2004.09.018

1873-3581

Ramakrishna G. Bhat, Yagnaseni Ghosh, Srinivasan Chandrasekaran,

Chemical Synthesis and Analysis

Alkyl groups can be cleaved efficiently and selectively from tertiary alkyl amines using propargyl chloroformate. The propargyloxycarbonyl (Poc) protected secondary amines thus obtained can be deblocked under neutral and mild conditions using benzyltriethylammonium tetrathiomolybdate. The generality and compatibility of the method have been studied with a wide range of functionalities.