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Reanalysis of Coreceptor Tropism in HIV-1-Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

2011; Oxford University Press; Volume: 52; Issue: 7 Linguagem: Inglês

10.1093/cid/cir072

1537-6591

Timothy Wilkin, Matthew Bidwell Goetz, Robert Leduc, Gail Skowron, Zhaohui Su, Edwin SY Chan, Jayvant Heera, Doug Chapman, J. Spritzler, J. D. Reeves, Roy M. Gulick, Eoin Coakley,

Mosquito-borne diseases and control

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1–infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.