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Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas

2003; Oxford University Press; Volume: 32; Issue: 1 Linguagem: Inglês

10.1093/ije/dyg004

1464-3685

Tomomi Marugame, Emiko Tsuji, Chikako Kiyohara, Hiroyuki Eguchi, Oda T, Koichi Shinchi, Suminori Kono,

Iron Metabolism and Disorders

Background Folate intake may be related to decreased risk of colorectal cancer and adenomas. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. We examined the relation between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of MTHFR.