Effect of Magnesium Citrate on the in Vitro Adsorption of Aspirin by Activated Charcoal
1981; Informa; Volume: 18; Issue: 7 Linguagem: Inglês
10.3109/15563658108990306
ISSN0009-9309
AutoresGinette Lapierre, Gary Algozzine, Paul L. Doering,
Tópico(s)Poisoning and overdose treatments
ResumoThe objective of this study was to determine if magnesium citrate solution given concurrently with activated charcoal would affect charcoal's in vitro ability to bind aspirin. Aspirin and charcoal were mixed in simulated gastric fluid and simulated intestinal fluid, and then magnesium citrate solution was added in proportions simulating those encountered clinically. Results indicate that no clinically significant interaction occurs between magnesium citrate and activated charcoal in either fluid, and that these two agents can be given simultaneously without decreasing the binding capacity for aspirin.
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