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Anaplastic Large Cell Lymphoma Involving the Breast: A Clinicopathologic Study of 6 Cases and Review of the Literature

2009; American Medical Association; Volume: 133; Issue: 9 Linguagem: Inglês

10.1043/1543-2165-133.9.1383

1543-2165

Roberto N. Miranda, Lin Lin, Sameer S. Talwalkar, John T. Manning, L. Jeffrey Medeiros,

Breast Cancer Treatment Studies

Abstract Context.—Lymphomas involving the breast are rare, and most cases are of B-cell lineage; T-cell neoplasms represent less than 10% of all breast lymphomas. Objective.—To define the clinicopathologic spectrum of anaplastic large cell lymphomas (ALCLs) involving the breast. Design.—Six cases of ALCL involving the breast were identified at a single institution during 21 years. The clinicopathologic and immunophenotypic features are presented, and the literature is reviewed. Results.—All patients were women, with a median age of 52 years. There were 4 anaplastic lymphoma kinase– negative (ALK−) ALCL cases; 3 of these neoplasms developed around breast implants. Two patients with ALK− ALCL had a history of cutaneous ALCL. There were 2 ALK+ ALCLs; both patients had stage IV disease. Histologically, all neoplasms were composed of large anaplastic cells that were uniformly CD30+ and expressed markers of T-cell lineage. Four patients with adequate follow-up are alive, with a mean of 4.1 years (range, 1.5–9 y...