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Striking diversity of DR15 haplotypes in Croatians

1997; Wiley; Volume: 49; Issue: 2 Linguagem: Inglês

10.1111/j.1399-0039.1997.tb02734.x

1399-0039

Zorana Grubić, Renata Žunec, A Kaštelan,

T-cell and B-cell Immunology

Analysis of HLA class II polymorphism revealed DR2 as the most frequent antigen in Croatians (20, 9%). The observed DR2 subtypes and their frequencies were as follows: DRB1*1601 – 9.9%; 1501 – 8.5%; 1602 – 1.8%, 1502 – 1.4% and 1503 – 0.7%. Furthermore, analysis of probable DRB1‐DQA1‐DQB1 haplotype associations in unrelated individuals revealed a high diversity of DR15 haplotype associations. Now, to confirm this observation from unrelated individuals, family studies have been performed. Sixty‐eight families, with at least one parent and one offspring DR2 positive, have been studied. DRB1*1601‐DQA1*0102‐DQB1*0502 seems to be conserved haplotype in Croatians while DRB1*15 haplotypes showed extremely high diversity. Seven rare DR15 haplotypes are observed; six of these appear twice and one only once. Two haplotypes appear to be unique to Croatians: DRB1*1501‐DQA1*0102‐DQB1*0501 and DRB1* 1501‐DQA1*0102‐DQB1*0604. This confirmation of extremely high diversity of DR15 haplotypes in Croatians is a valuable tool for unrelated bone marrow transplantation and DR2 disease association studies.