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Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

2012; American Association for the Advancement of Science; Volume: 4; Issue: 136 Linguagem: Inglês

10.1126/scitranslmed.3003726

1946-6242

Tim Forshew, Muhammed Murtaza, Christine Parkinson, Davina Gale, Dana W.Y. Tsui, Fiona Kaper, Sarah‐Jane Dawson, Anna Piskorz, Mercedes Jimenez‐Liñan, David Bentley, James Hadfield, Andrew P. May, Carlos Caldas, James D. Brenton, Nitzan Rosenfeld,

CRISPR and Genetic Engineering

Sizable genomic regions were screened and low-frequency mutations were identified in circulating DNA of cancer patients using tagged-amplicon deep sequencing (TAm-Seq).