Portal de Periódicos da CAPES

Can we prevent Alzheimer's disease? Secondary “prevention” trials in Alzheimer's disease

2013; Wiley; Volume: 9; Issue: 2 Linguagem: Inglês

10.1016/j.jalz.2012.12.004

1552-5279

María C. Carrillo, H. Robert Brashear, Veronika Logovinsky, J. Michael Ryan, Howard Feldman, Eric Siemers, Susan Abushakra, Dean M. Hartley, Ronald C. Petersen, Ara S. Khachaturian, Reisa A. Sperling,

Health Systems, Economic Evaluations, Quality of Life

Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.