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Cannabis Use and Reduced Risk of Insulin Resistance in HIV-HCV Infected Patients: A Longitudinal Analysis (ANRS CO13 HEPAVIH)

2015; Oxford University Press; Volume: 61; Issue: 1 Linguagem: Inglês

10.1093/cid/civ217

1537-6591

Patrizia Carrieri, L. Serfaty, Antoine Vilotitch, M. Winnock, I. Poizot-Martin, M.‐A. Loko, C. Lions, C. Lascoux-Combe, Perrine Roux, Dominique Salmon‐Céron, B. Spire, F. Dabis, for the ANRS CO HEPAVIH Study Group, Dominique Salmon‐Céron, F. Dabis, M. Winnock, M. A. Loko, P. Sogni, Y. Benhamou, P. Trimoulet, J. Izopet, Valérie Paradis, B. Spire, Patrizia Carrieri, Christine Katlama, G. Pialoux, M. A. Valantin, P. Bonnard, I. Poizot-Martin, B. Marchou, E. Rosenthal, D. Garipuy, O. Bouchaud, A. Gervais, C. Lascoux-Combe, C. Goujard, Karine Lacombe, Claudine Duvivier, D. Vittecoq, D. Neau, P. Morlat, Firouzé Bani‐Sadr, Laurence Meyer, F. Boufassa, S. Dominguez, Brigitte Autran, A. M. Roque, Caroline Solas, Hélène Fontaine, L. Serfaty, Geneviève Chêne, D. Costagliola, D. Zucman, A. Simon, S. Dominguez, E. Billaud, P. Miailhes, J. P. Devoto, S. Couffin-Cadiergues, H. Mehawej, Frédéric Charlotte, Zinb Makhlouf, G. Dubost, F. Tessier, Laure Gibault, F. Beuvon, E. Chambon, T. Lazure, Anne Krivine, Christine Katlama, M. A. Valantin, H. Stitou, Y. Benhamou, Frédéric Charlotte, Slim Fourati, A. Simon, P. Cacoub, S. Nafissa, O. Zaegel, A. Ménard, P. Geneau, C. Tamalet, G. Pialoux, P. Bonnard, Firouzé Bani‐Sadr, L. Slama, Thomas L’Yavanc, P Callard, F. Bendjaballah, Catherine Lependeven, B. Marchou, L. Alric, Karl Barange, Sophie Métivier, Abbas Ali Imani Fooladi, J. Selves, F. Nicot, E. Rosenthal, J. Durant, Juliette Haudebourg, M Saint-Paul, O. Bouchaud, M. Ziol, Y. Baazia, M. Uzan, A. Bicart-See, D. Garipuy, M. J. Ferro-Collados, J. Selves, F. Nicot, P. Yéni, A. Gervais, Homa Adle‐Biassette, Jean‐Michel Molina, C. Lascoux Combe, P. Bertheau, J M Duclos, P. Palmer, Philippe Girard, Karine Lacombe, P. Campa, D. Wendum, P. Cervera, Julien Adam, N. Harchi, Jean‐François Delfraissy, C. Goujard, Yann Quertainmont, C. Pallier, D. Vittecoq, O. Lortholary, Claudine Duvivier, M. Shoai-Tehrani, D. Neau, P. Morlat, L. Lacaze-Buzy, S. Caldato, P. Bioulac‐Sage, P. Trimoulet, Sandrine Reigadas, D. Zucman, C. Majerholc, F. Guitard, François Boué, J. P. Devoto, Imad Kansau, V. Chambrin, C. Pignon, L. Berroukeche, R Fior, V. Martinez, Claire Deback, Yves Lévy, S. Dominguez, Jean‐Daniel Lelièvre, A.-S. Lascaux, Giovanna Melica, François Raffi, E. Billaud, C. Alavena, A. Rodallec, D. Peyramond, C. Chidiac, P. Miailhes, Florence Ader, F. Biron, A. Boibieux, Laurent Cotte, Tristan Ferry, T. Perpoint, J. Koffi, Fabien Zoulim, François Bailly, Philippe Lack, M. Travis Maynard, Sylvie Radenne, M. Amiri, D. Beniken, A. S. Ritleng, Madona Azar, Patrick M. Honoré, S. Breau, A. Joulié, M.Leonard Mole, C. Bolliot, F. Chouraqui, F. Touam, Fiona André, N. Ouabdesselam, C. Partouche, Guy P. Alexandre, Amandine Ganon, A. Champetier, H Hüe, D. Brosseau, C. Brochier, V. Thoirain, Marie‐Thérèse Rannou, Dominique Bornarel, S. Gillet, J. Delaune, Élodie Pambrun, L. Dequae-Merchadou, Anne Frosch, Gwenaëlle Maradan, O. Cheminat, F. Marcellin, Marion Mora, Camélia Protopopescu, Perrine Roux, C. Lions, M.‐A. Loko, M. Winnock,

Diabetes Treatment and Management

Background. Diabetes and insulin resistance (IR) is common in human immunodeficiency virus–hepatitis C virus (HIV–HCV)-coinfected patients, a population also concerned with elevated cannabis use. Cannabis has been associated with reduced IR risk in some population-based surveys. We determined whether cannabis use was consistently associated with reduced IR risk in HEPAVIH, a French nationwide cohort of HIV–HCV-coinfected patients. Methods. HEPAVIH medical and sociobehavioral data were collected (using annual self-administered questionnaires). We used 60 months of follow-up data for patients with at least 1 medical visit where IR (using homeostatic model assessment of insulin resistance [HOMA-IR]) and cannabis use were assessed. A mixed logistic regression model was used to evaluate the association between IR risk (HOMA-IR > 2.77) and cannabis use (occasional, regular, daily). Results. Among the 703 patients included in the study (1287 visits), 323 (46%) had HOMA-IR > 2.77 for at least 1 follow-up visit and 319 (45%) reported cannabis use in the 6 months before the first available visit. Cannabis users (irrespective of frequency) were less likely to have HOMA-IR > 2.77 (odds ratio [95% confidence interval], 0.4 [.2–.5]) after adjustment for known correlates/confounders. Two sensitivity analyses with HOMA-IR values as a continuous variable and a cutoff value of 3.8 confirmed the association between reduced IR risk and cannabis use. Conclusions. Cannabis use is associated with a lower IR risk in HIV–HCV-coinfected patients. The benefits of cannabis-based pharmacotherapies for patients concerned with increased risk of IR and diabetes need to be evaluated in clinical research and practice.