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DEVICE-BASED BRAIN STIMULATION TO AUGMENT FEAR EXTINCTION: IMPLICATIONS FOR PTSD TREATMENT AND BEYOND

2014; Wiley; Volume: 31; Issue: 4 Linguagem: Inglês

10.1002/da.22252

1520-6394

Marie‐France Marin, Joan A. Camprodon, Darin D. Dougherty, Mohammed R. Milad,

Nicotinic Acetylcholine Receptors Study

Depression and AnxietyVolume 31, Issue 4 p. 269-278 2013 ADAA Scientific Symposium DEVICE-BASED BRAIN STIMULATION TO AUGMENT FEAR EXTINCTION: IMPLICATIONS FOR PTSD TREATMENT AND BEYOND Marie-France Marin Ph.D., Marie-France Marin Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorJoan A. Camprodon M.D., M.P.H., Ph.D., Joan A. Camprodon M.D., M.P.H., Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorDarin D. Dougherty M.D., M.Sc., Darin D. Dougherty M.D., M.Sc. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorMohammed R. Milad Ph.D., Corresponding Author Mohammed R. Milad Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsCorrespondence to: Mohammed R. Milad, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Office 2614, Charlestown, Boston, MA 02129. E-mail: [email protected]Search for more papers by this author Marie-France Marin Ph.D., Marie-France Marin Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorJoan A. Camprodon M.D., M.P.H., Ph.D., Joan A. Camprodon M.D., M.P.H., Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorDarin D. Dougherty M.D., M.Sc., Darin D. Dougherty M.D., M.Sc. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorMohammed R. Milad Ph.D., Corresponding Author Mohammed R. Milad Ph.D. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, MassachusettsCorrespondence to: Mohammed R. Milad, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Office 2614, Charlestown, Boston, MA 02129. E-mail: [email protected]Search for more papers by this author First published: 13 March 2014 https://doi.org/10.1002/da.22252Citations: 70 Contract grant sponsor: Department of Defense; Contract grant number: W81XWH-11-2-0079. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Conditioned fear acquisition and extinction paradigms have been widely used both in animals and humans to examine the neurobiology of emotional memory. Studies have also shown that patients suffering from posttraumatic stress disorder (PTSD) exhibit deficient extinction recall along with dysfunctional activation of the fear extinction network, including the ventromedial prefrontal cortex, amygdala, and hippocampus. A great deal of overlap exists between this fear extinction network and brain regions associated with symptom severity in PTSD. This suggests that the neural nodes of fear extinction could be targeted to reduce behavioral deficits that may subsequently translate into symptom improvement. In this article, we discuss potential applications of brain stimulation and neuromodulation methods, which, combined with a mechanistic understanding of the neurobiology of fear extinction, could be used to further our understanding of the pathophysiology of anxiety disorders and develop novel therapeutic tools. To this end, we discuss the following stimulation approaches: deep-brain stimulation, vagus nerve stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation. We propose new translational research avenues that, from a systems neuroscience perspective, aim to expand our understanding of circuit dynamics and fear processing toward the practical development of clinical tools, to be used alone or in combination with behavioral therapies. Citing Literature Volume31, Issue4April 2014Pages 269-278 RelatedInformation