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Bridgehead enolates and bridgehead alkenes in a welwistatin model series

2009; Royal Society of Chemistry; Issue: 11 Linguagem: Inglês

10.1039/b820674k

1364-548X

Valerie Boissel, Nigel S. Simpkins, Gurdip Bhalay, Alexander J. Blake, William Lewis,

Coordination Chemistry and Organometallics

Bridgehead metallation is possible in a ketone having the welwistatin skeleton, and this facilitates installation of the isothiocyanate function present in the natural product, and also enables synthesis of remarkable bridgehead alkenes.