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Rates of Biochemical Remission Remain Higher in Black Men Compared to White Men After Radical Prostatectomy Despite Similar Trends in Prostate Specific Antigen Induced Stage Migration

2007; Lippincott Williams & Wilkins; Volume: 178; Issue: 4 Linguagem: Inglês

10.1016/j.juro.2007.05.127

1527-3792

Hadley Wood, Alwyn M. Reuther, Timothy D. Gilligan, Patrick A. Kupelian, Charles S. Modlin, Eric A. Klein,

Molecular Biology Techniques and Applications

No AccessJournal of UrologyAdult urology1 Oct 2007Rates of Biochemical Remission Remain Higher in Black Men Compared to White Men After Radical Prostatectomy Despite Similar Trends in Prostate Specific Antigen Induced Stage Migration Hadley M. Wood, Alwyn M. Reuther, Timothy D. Gilligan, Patrick A. Kupelian, Charles S. Modlin, and Eric A. Klein Hadley M. WoodHadley M. Wood Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio , Alwyn M. ReutherAlwyn M. Reuther Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio , Timothy D. GilliganTimothy D. Gilligan Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio , Patrick A. KupelianPatrick A. Kupelian Radiation Oncology, M. D. Anderson Cancer Center Orlando, Orlando, Florida , Charles S. ModlinCharles S. Modlin Minority Mens' Health Center, Cleveland Clinic, Cleveland, Ohio Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio , and Eric A. KleinEric A. Klein Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio View All Author Informationhttps://doi.org/10.1016/j.juro.2007.05.127AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated biochemical relapse-free survival after surgery for localized prostate cancer, comparing rates between black and white men in the early and late prostate specific antigen eras. Our hypothesis was that the gap in biochemical relapse-free survival between these groups would lessen in the later prostate specific antigen era due to catch-up awareness/availability of screening and treatment in the black population. Materials and Methods: Data on 2,910 men treated with prostatectomy from 1987 to 2004 were evaluated. The primary end points were 1) rates of organ confined disease and 2) biochemical relapse-free survival after prostatectomy in the early (1987 to 1997) and late (1998 to 2004) prostate specific antigen eras. Rates of organ confined disease were compared using the chi-square test. Biochemical failure was analyzed using Kaplan-Meier estimates and Cox proportional hazards regression. Results: Median followup for the early and late prostate specific antigen periods was 9.8 (range 1.2 to 18.2) and 3.3 years (range 1.0 to 7.7), respectively. Based on rates of organ confined disease in the early vs late periods black and white men had significant gains in the number presenting with favorable disease at diagnosis in the late prostate specific antigen period (54% vs 76% and 49% vs 71%, respectively, each p <0.01). Despite gains of similar magnitude in favorable features at presentation biochemical relapse-free survival for black men lagged behind white men by 11% at 5 years in the early era and by 12% in the late era. Race was a significant predictor of biochemical relapse-free survival on multivariate analysis in each era. Conclusions: Despite similar increases in the rate of organ confined disease between black and white men in the late vs early prostate specific antigen eras black men continue to show higher rates of biochemical failure after surgery. References 1 : Racial differences in mortality among Medicare recipients after treatment for localized prostate cancer. J Natl Cancer Inst2003; 95: 1702. Google Scholar 2 United States Census 2000. United States Census Bureau. Available at http://www.census.gov/main/www/cen2000.html. Accessed April 15, 2006. Google Scholar 3 : Race as an independent predictor of outcome after treatment for localized prostate cancer. J Urol1999; 162: 1331. 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Google Scholar 20 : Racial differences in screening for prostate cancer in the elderly. Arch Intern Med2004; 164: 1858. Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetails Volume 178Issue 4October 2007Page: 1271-1276 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsEuropean continental ancestry groupprostatic neoplasmsprostate-specific antigenAfrican AmericansprostateMetricsAuthor Information Hadley M. Wood Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Alwyn M. Reuther Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Timothy D. Gilligan Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio More articles by this author Patrick A. Kupelian Radiation Oncology, M. D. Anderson Cancer Center Orlando, Orlando, Florida More articles by this author Charles S. Modlin Minority Mens' Health Center, Cleveland Clinic, Cleveland, Ohio Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Eric A. Klein Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Expand All Advertisement PDF DownloadLoading ...