Endothelial regrowth after arterial injury: from vascular repair to therapeutics
1998; Oxford University Press; Volume: 38; Issue: 1 Linguagem: Inglês
10.1016/s0008-6363(97)00326-x
ISSN1755-3245
Autores Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoInterventional strategies for patients with coronary artery disease such as percutaneous transluminal coronary angioplasty or coronary stent implantation invariably result in a Ž marked degree of vascular injury deendothelialization, .mechanical damage to the medial and adventitial layers w x 1-3 .The loss of the endothelial monolayer is associated with a variety of deleterious consequences such as thrombus formation, neointimal thickening, and abnormal responses w x to endothelium-dependent agonists 3-5 .These effects may contribute to each of the known limitations of these Ž .techniques vessel occlusion, restenosis, coronary spasm .The objective of the present review will be to present applied reendothelialization as a possible treatment for patients with coronary artery disease undergoing mechanical revascularization.Our aim will be twofold: first, to summarize current knowledge on the beneficial effect of endothelial regrowth after arterial injury; second, to discuss the potential role of growth factors or other compounds to accelerate reendothelialization. The 'normal' endothelial layerOccupying a strategically important location between circulating blood and tissues and having the ability to respond to changes in its physical, chemical, and humoral environment by the production of bioactive substances, the normal endothelium controls the tone and the proliferative state of the underlying vascular smooth muscle cells Ž .VSMCs and maintains a non-adhesive luminal surface.
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