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Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study

2013; SAGE Publishing; Volume: 19; Issue: 11 Linguagem: Inglês

10.1177/1352458513501231

1477-0970

Giancarlo Comi, MA Battaglia, Antonio Bertolotto, Massimo Del Sette, Angelo Ghezzi, Giovanni Malferrari, Marco Salvetti, Maria Pia Sormani, Luigi Tesio, Erwin Stolz, Paola Zaratin, Gianluigi Mancardi, Claudio Baracchini, Roberto Bergamaschi, Antonio Bertolotto, F. Bortolon, Alessio Bratina, Vincenzo Brescia Morra, Maria Buccafusca, Marco Busso, Ruggero Capra, Nicola Carraro, Paola Cavalla, Pietro Cecconi, Diego Centonze, Domenico Ciampanelli, Maurilio Cirrito, Alessandro Ciuffoli, Giancarlo Comi, Lorenzo Coppo, Gianfranco Costantino, Salvatore Cottone, Antonella Deboni, Massimo Del Sette, Nicola De Rossi, Di Luca, Elisabetta Favaretto, Cinzia Finocchi, Roberta Gaeta, Paolo Gallo, Angelo Ghezzi, Bruno Giometto, Enrico Granieri, Silvia Grazioli, Luigi M.E. Grimaldi, Angelo Guccione, Francesco Iemolo, Piergiorgio Lochner, Alessandra Lugaresi, Davide Maimone, Giovanni Malferrari, Gianluigi Mancardi, Marcello Mancini, Renato Mantegazza, Maria Giovanna Marrosu, Elisabetta Menci, Lucia Monti, Luisa Motti, Grazia M Nuzzaco, Lucia Pascazio, Francesco Patti, Alessandra Protti, Leandro Provinciali, Denis Rossato, Marco Rovaris, Marco Salvetti, Sandro Sanguigni, Enzo Sanzaro, Giuliano Sette, M. Spinelli, S. Stecchi, Matteo Stefanini, Frediano Tezzon, Maria Rosaria Tola, Simone Tonello, Maria Trojano, Monica Ulivelli, S Uselli, Federica Viaro, Paola Zaratin, Marialuisa Zedde,

Sinusitis and nasal conditions

Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS).The CoSMo study evaluated the association between CCSVI and MS.The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded.The study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers.CCSVI is not associated with MS.