Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues
2000; Wiley; Volume: 6; Issue: 15 Linguagem: Inglês
10.1002/1521-3765(20000804)6
ISSN1521-3765
AutoresK. C. Nicolaou, David Hepworth, N. Paul King, M. Raymond V. Finlay, Rita Scarpelli, M. Manuela A. Pereira, Birgit Bollbuck, Antony Bigot, Barbara Werschkun, Nicolas Winssinger,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoThe macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57a-57g, dimeric epothilones 59 and 61, and benzenoid epothilones 63a-63g.
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