Cardiac development in zebrafish: coordination of form and function
2002; Elsevier BV; Volume: 13; Issue: 6 Linguagem: Inglês
10.1016/s1084952102001040
ISSN1096-3634
AutoresNathalia S Glickman, Deborah Yelon,
Tópico(s)Zebrafish Biomedical Research Applications
ResumoOrganogenesis is a dynamic process involving multiple phases of pattern formation and morphogenesis. For example, heart formation involves the specification and differentiation of cardiac precursors, the integration of precursors into a tube, and the remodeling of the embryonic tube to create a fully functional organ. Recently, the zebrafish has emerged as a powerful model organism for the analysis of cardiac development. In particular, zebrafish mutations have revealed specific genetic requirements for cardiac fate determination, migration, fusion, tube assembly, looping, and remodeling. These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis.
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