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A novel method for the generation of (R)- and (S)-3-chloro-1,2-propanediol by stereospecific dehalogenating bacteria and their use in the preparation of (R)- and (S)-Glycidol

1991; Elsevier BV; Volume: 1; Issue: 7 Linguagem: Inglês

10.1016/s0960-894x(01)80468-6

1464-3405

Toshio Suzuki, Noaya Kasai,

Analytical Chemistry and Chromatography

A novel and effective method for the preparation of highly pure optically active (R)- and (S)-3-chloro-1,2-propanediol (99.5% ee and 99.4% ee, respectively) was established based on stereospecific dehalogenation and assimilation with bacteria. From these intermediates highly pure optically active (R)- and (S)-glycidol (99.3% ee and 99.4% ee, respectively) were prepared.