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1‐( o ‐Nitrophenyl)‐2,2,2‐trifluoroethyl Ether Derivatives as Stable and Efficient Photoremovable Alcohol‐Protecting Groups

2004; Wiley; Volume: 43; Issue: 15 Linguagem: Inglês

10.1002/anie.200353247

1521-3773

Alexandre Specht, Maurice Goeldner,

Radical Photochemical Reactions

The caging and photolytic release of alcohols has enormous potential for application in biological chemistry. A variety of stable 1-(2-nitrophenyl)-2,2,2-trifluoroethyl ether derivatives, which were readily prepared through Mitsunobu coupling reactions with an alcohol (ROH), underwent photolytic cleavage in high quantum yields (see scheme; R=alkyl, R′=H, OCH3).