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Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming

2006; BMJ; Volume: 78; Issue: 3 Linguagem: Inglês

10.1136/jnnp.2006.095315

1468-330X

Michael S. Okun, Govind Singh Mann, Kelly D. Foote, Nathan A. Shapira, Dawn Bowers, Utaka Springer, Wiley Knight, Pam Martin, Wayne K. Goodman,

Neurotransmitter Receptor Influence on Behavior

Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD). This region has been previously explored with lesion therapy, but with the advent of DBS there exists the possibility of monitoring the acute and chronic effects of electrical stimulation. The stimulation-induced benefits and side effects can be reversibly and blindly applied to a variety of locations in this region.