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Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

2014; Associação Brasileira de Psiquiatria; Volume: 36; Issue: 4 Linguagem: Inglês

10.1590/1516-4446-2014-1380

1809-452X

Izabela Guimarães Barbosa, Isabela Boechat Morato, Rodrigo Barreto Huguet, Fábio Lopes Rocha, Rodrigo Machado‐Vieira, Antônio Lúcio Teixeira,

Adenosine and Purinergic Signaling

To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.