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A synthesis of (−)-tetrahydrolipstatin in which the relative stereochemistry is controlled by a phenyldimethylsilyl group

1990; Elsevier BV; Volume: 31; Issue: 25 Linguagem: Inglês

10.1016/s0040-4039(00)94466-6

1873-3581

Ian Fleming, Nicholas J. Lawrence,

Asymmetric Synthesis and Catalysis

The alkylation ofa β-silylenolate and the hydroboration of an allylsilane successively control the relative stereochemistry of the three stereogenic centres on the carbon backbone in a synthesis of the esterase inhibitor tetrahydrolipstatin (21).