Philadelphia Chromosome–Positive Acute Lymphocytic Leukemia
2001; Elsevier BV; Volume: 15; Issue: 1 Linguagem: Inglês
10.1016/s0889-8588(05)70198-2
ISSN1558-1977
Autores Tópico(s)Chronic Lymphocytic Leukemia Research
ResumoThe Philadelphia (Ph) chromosome was the first cancer-specific translocation discovered.44 It is the hallmark genetic lesion found in chronic myeloid leukemia (CML), is found less commonly in acute lymphocytic leukemia (ALL), and is rarely found in acute myelogenous leukemia (AML). The Ph chromosome is present in approximately 20% of adult ALL and in approximately 5% of pediatric ALL.59, 69 The Ph chromosome provides the model for a specific genetic lesion that is associated with a distinct prognosis, can serve as a marker for detection of early relapse using sophisticated and sensitive molecular assays, and has a specific molecular pathogenesis that provides an opportunity for truely targeted therapy.
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