Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue 1
2003; Wiley; Volume: 554; Issue: 3 Linguagem: Inglês
10.1016/s0014-5793(03)01212-2
ISSN1873-3468
AutoresEmma E. Tarttelin, James Bellingham, Mark W. Hankins, F. Foster, Robert J. Lucas,
Tópico(s)Neurobiology and Insect Physiology Research
ResumoWe have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.
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