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Prospective randomized study of sulindac versus calcium and calciferol for upper gastrointestinal polyps in familial adenomatous polyposis

1996; Oxford University Press; Volume: 83; Issue: 12 Linguagem: Inglês

10.1002/bjs.1800831232

1365-2168

Francis Seow‐Choen, Viji Vijayan, Vincent W. Keng,

Inflammatory mediators and NSAID effects

Abstract Eighteen patients with familial adenomatous polyposis (FAP) who had previously undergone colectomy but had upper gastrointestinal polyps were studied in a double-blind randomized crossover trial comparing sulindac with calcium and calciferol. Sulindac produced a reduction in the crypt proliferation index in the gastric epithelium of patients but did not significantly affect duodenal mucosa. Calcium with calciferol did not have any effects on crypt proliferation index in patients with FAP.