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Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

2014; Wiley; Volume: 10; Issue: 12 Linguagem: Inglês

10.1002/term.1890

1932-7005

Johannes Holfeld, Daniel Zimpfer, Karin Albrecht-Schgoer, Alexander Stojadinovic, Patrick Paulus, Julia Dumfarth, Anita Thomas, Daniela Lobenwein, Can Gollmann‐Tepeköylü, Raphaël Rosenhek, Wolfgang Schaden, Rudolf Kirchmair, Seyedhossein Aharinejad, Michael Grimm,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

Journal of Tissue Engineering and Regenerative MedicineVolume 10, Issue 12 p. 1057-1064 Research Article Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease Johannes Holfeld, Johannes Holfeld Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorDaniel Zimpfer, Daniel Zimpfer Department of Cardiac Surgery, Medical University of Vienna, AustriaSearch for more papers by this authorKarin Albrecht-Schgoer, Karin Albrecht-Schgoer Department of Internal Medicine I, Innsbruck Medical University, AustriaSearch for more papers by this authorAlexander Stojadinovic, Alexander Stojadinovic Combat Wound Initiative Program, Walter Reed Army Medical Center, Washington, DC, Uniformed Services University of the Health Sciences, Bethesda, MD, USASearch for more papers by this authorPatrick Paulus, Patrick Paulus Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, GermanySearch for more papers by this authorJulia Dumfarth, Julia Dumfarth Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorAnita Thomas, Anita Thomas Gender Medicine Unit, Department of Internal Medicine III, Medical University of Vienna, AustriaSearch for more papers by this authorDaniela Lobenwein, Daniela Lobenwein Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorCan Tepeköylü, Can Tepeköylü Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorRaphael Rosenhek, Raphael Rosenhek Department of Internal Medicine II, Medical University of Vienna, AustriaSearch for more papers by this authorWolfgang Schaden, Wolfgang Schaden AUVA Trauma Centre Meidling, Vienna, AustriaSearch for more papers by this authorRudolf Kirchmair, Rudolf Kirchmair Combat Wound Initiative Program, Walter Reed Army Medical Center, Washington, DC, Uniformed Services University of the Health Sciences, Bethesda, MD, USASearch for more papers by this authorSeyedhossein Aharinejad, Seyedhossein Aharinejad Department of Cardiac Surgery, Medical University of Vienna, Austria Laboratory for Cardiovascular Research, Department of Anatomy and Cell Biology, Medical University of Vienna, AustriaSearch for more papers by this authorMichael Grimm, Corresponding Author Michael Grimm michael.grimm@uki.at Department of Cardiac Surgery, Innsbruck Medical University, AustriaCorrespondence to: Michael Grimm, Department of Cardiac Surgery, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. E-mail: michael.grimm@uki.atSearch for more papers by this author Johannes Holfeld, Johannes Holfeld Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorDaniel Zimpfer, Daniel Zimpfer Department of Cardiac Surgery, Medical University of Vienna, AustriaSearch for more papers by this authorKarin Albrecht-Schgoer, Karin Albrecht-Schgoer Department of Internal Medicine I, Innsbruck Medical University, AustriaSearch for more papers by this authorAlexander Stojadinovic, Alexander Stojadinovic Combat Wound Initiative Program, Walter Reed Army Medical Center, Washington, DC, Uniformed Services University of the Health Sciences, Bethesda, MD, USASearch for more papers by this authorPatrick Paulus, Patrick Paulus Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, GermanySearch for more papers by this authorJulia Dumfarth, Julia Dumfarth Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorAnita Thomas, Anita Thomas Gender Medicine Unit, Department of Internal Medicine III, Medical University of Vienna, AustriaSearch for more papers by this authorDaniela Lobenwein, Daniela Lobenwein Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorCan Tepeköylü, Can Tepeköylü Department of Cardiac Surgery, Innsbruck Medical University, AustriaSearch for more papers by this authorRaphael Rosenhek, Raphael Rosenhek Department of Internal Medicine II, Medical University of Vienna, AustriaSearch for more papers by this authorWolfgang Schaden, Wolfgang Schaden AUVA Trauma Centre Meidling, Vienna, AustriaSearch for more papers by this authorRudolf Kirchmair, Rudolf Kirchmair Combat Wound Initiative Program, Walter Reed Army Medical Center, Washington, DC, Uniformed Services University of the Health Sciences, Bethesda, MD, USASearch for more papers by this authorSeyedhossein Aharinejad, Seyedhossein Aharinejad Department of Cardiac Surgery, Medical University of Vienna, Austria Laboratory for Cardiovascular Research, Department of Anatomy and Cell Biology, Medical University of Vienna, AustriaSearch for more papers by this authorMichael Grimm, Corresponding Author Michael Grimm michael.grimm@uki.at Department of Cardiac Surgery, Innsbruck Medical University, AustriaCorrespondence to: Michael Grimm, Department of Cardiac Surgery, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. E-mail: michael.grimm@uki.atSearch for more papers by this author First published: 19 May 2014 https://doi.org/10.1002/term.1890Citations: 27Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in a rat model of myocardial infarction. In the present experiments we aimed to address the safety and efficacy of epicardial shock-wave therapy in a preclinical large animal model and to further evaluate mechanisms of action of this novel therapy. Four weeks after left anterior descending (LAD) artery ligation in pigs, the animals underwent re-thoracotomy with (shock-wave group, n = 6) or without (control group, n = 5) epicardial shock waves (300 impulses at 0.38 mJ/mm2) applied to the infarcted anterior wall. Efficacy endpoints were improvement of LVEF and induction of angiogenesis 6 weeks after shock-wave therapy. Safety endpoints were haemodynamic stability during treatment and myocardial damage. Four weeks after LAD ligation, LVEF decreased in both the shock-wave (43 ± 3%, p < 0.001) and control (41 ± 4%, p = 0.012) groups. LVEF markedly improved in shock-wave animals 6 weeks after treatment (62 ± 9%, p = 0.006); no improvement was observed in controls (41 ± 4%, p = 0.36), yielding a significant difference. Quantitative histology revealed significant angiogenesis 6 weeks after treatment (controls 2 ± 0.4 arterioles/high-power field vs treatment group 9 ± 3; p = 0.004). No acute or chronic adverse effects were observed. As a potential mechanism of action in vitro experiments showed stimulation of VEGF receptors after shock-wave treatment in human coronary artery endothelial cells. Epicardial shock-wave treatment in a large animal model of ischaemic heart failure exerted a positive effect on LVEF improvement and did not show any adverse effects. Angiogenesis was induced by stimulation of VEGF receptors. Copyright © 2014 John Wiley & Sons, Ltd. Citing Literature Volume10, Issue12December 2016Pages 1057-1064 RelatedInformation