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Macrolide-Resistant Shigella sonnei

2008; Centers for Disease Control and Prevention; Volume: 14; Issue: 8 Linguagem: Inglês

10.3201/eid1408.080147

1080-6059

Leyla Boumghar-Bourtchaï, Patricia Mariani‐Kurkdjian, Édouard Bingen, Ingrid Filliol, Anne Dhalluin, Shadia Ait Ifrane, François‐Xavier Weill, Roland Leclercq,

Clostridium difficile and Clostridium perfringens research

Abstract Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.