In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides
2001; American Society for Microbiology; Volume: 45; Issue: 11 Linguagem: Inglês
10.1128/aac.45.11.3209-3212.2001
ISSN1098-6596
AutoresGudmundur Bergsson, Jóhann Arnfinnsson, Ólafur Steingrı́msson, Halldór Thormar,
Tópico(s)Pneumonia and Respiratory Infections
ResumoABSTRACT The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.
Referência(s)