Natural killer cell activity associated with aging and sex in humans.
1983; The Japanese Society of Internal Medicine; Volume: 22; Issue: 3 Linguagem: Inglês
10.2169/internalmedicine1962.22.195
ISSN1881-123X
AutoresEiji Sugiyama, Masami Ito, Hidehiko Suzuki, Naohiro Yamashita, Muneharu Maruyama, Saburo Yano,
Tópico(s)Acute Myeloid Leukemia Research
ResumoThe effect of aging and sex on natural killer (NK) cell activity in humans was investigated. The results showed that there were no significant differences in both the age- and sex-related NKcell activities with or without polyinosinic acid-polycytidylie acid stimulation. On the other hand, the mitogenic response of peripheral blood lymphocytes in the aged group (aged 70 to 86 years) was found to be significantly depressed in compared with that in the young adult group (aged 20 to 30 years). These data suggest that the NKcell activity of the aged subjects is operative, and may be important in defense against neoplasia since extensive immunodeficiencies are knownto be associated with aging.
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