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International network of cancer genome projects

2010; Nature Portfolio; Volume: 464; Issue: 7291 Linguagem: Inglês

10.1038/nature08987

1476-4687

Thomas J. Hudson, Warwick P. Anderson, Axel Aretz, Anna D. Barker, Cindy Bell, Rosa R. Bernabé, M. K. Bhan, Fabien Calvo, Iiro Eerola, Daniela S. Gerhard, Alan F. Guttmacher, Mark S. Guyer, Fiona M. Hemsley, Jennifer L. Jennings, David Kerr, Peter Klatt, Patrik Kolar, Jun Kusuda, David P. Lane, Frank Laplace, Youyong Lu, Gerd Nettekoven, Brad Ozenberger, Jane L. Peterson, T. S. Rao, Jacques Remacle, Alan J. Schafer, Tatsuhiro Shibata, Michael R. Stratton, Joseph G. Vockley, Koichi Watanabe, Huanming Yang, M.M.F. Yuen, Bartha Maria Knoppers, Martin Bobrow, Anne Cambon‐Thomsen, Lynn G. Dressler, Stephanie O. M. Dyke, Yann Joly, Yoshihiro Kato, Karen L. Kennedy, Pilar Nicolás, Michael Parker, Emmanuelle Rial‐Sebbag, Carlos M. Romeo-Casabona, Kenna M. Shaw, Susan Wallace, Georgia L. Wiesner, Nikolajs Zeps, Peter Lichter, Andrew V. Biankin, Christian Chabannon, Lynda Chin, Bruno Clément, Enrique de Álava, Françoise Degos, Martin L. Ferguson, Peter Geary, D. Neil Hayes, Amber L. Johns, Arek Kasprzyk, Hidewaki Nakagawa, Robert Penny, Miguel Á. Piris, Rajiv Sarin, Aldo Scarpa, Marc J. van de Vijver, P. Andrew Futreal, Hiroyuki Aburatani, Mónica Bayés, David D.L. Bowtell, Peter J. Campbel, Xavier Estivill, Sean M. Grimmond, Ivo Gut, Martin Hirst, Carlos López-Otı́n, Partha Majumder, Marco A. Marra, John D. McPherson, Zemin Ning, Xosé S. Puente, Yijun Ruan, H.G. Stunnenberg, Harold Swerdlow, Victor E. Velculescu, Richard K. Wilson, Hong Xue, Liu Yang, Paul T. Spellman, Gary D. Bader, Paul C. Boutros, Paul Flicek, Gad Getz, Roderic Guigó, Guangwu Guo, David Haussler, Simon Heath, Tim Hubbard, Tao Jiang, Steven J.M. Jones, Qibin Li, Núria López-Bigas, Ruibang Luo, Lakshmi Muthuswamy, B. F. Francis Ouellette, John V. Pearson, Vı́ctor Quesada, Benjamin J. Raphael, Chris Sander, Terence P. Speed, Lincoln D. Stein, Joshua M. Stuart, Jon W. Teague, Yasushi Totoki, Tatsuhiko Tsunoda, Alfonso Valencia, David A. Wheeler, Honglong Wu, Shancen Zhao, Guangyu Zhou, Mark Lathrop, Anthony J. Gill, Teruhiko Yoshida, Myles Axton, Chris Gunter, Linda J. Miller, Junjun Zhang, Syed Haider, Jianxin Wang, Christina K. Yung, Anthony Cross, Yong Liang, Saravanamuttu Gnaneshan, Jonathan M. Guberman, Jack Shih‐Chieh Hsu, Drc Chalmers, Karl W. Hasel, Terry Sheung-Hung Kaan, William W. Lowrance, Tohru Masui, Laura Lyman Rodriguez, Catherine Vergely, David D L Bowtel, Nicole Cloonan, Anna deFazio, James R. Eshleman, Dariush Etemadmoghadam, Brooke A. Gardiner, James G. Kench, Robert L. Sutherland, Margaret A. Tempero, Nicola Waddell, Peter J. Wilson, Steve Gallinger, Ming‐Sound Tsao, Patricia Shaw, Gloria M. Petersen, Debabrata Mukhopadhyay, Ronald A. DePinho, Sarah P. Thayer, Kamran Shazand, Timothy Beck, Michelle Sam, Lee E. Timms, Vanessa Ballin, Jiafu Ji, Xiuqing Zhang, Feng Chen, Xueda Hu, Qi Yang, Geng Tian, Lianhai Zhang, Xiaofang Xing, Xianghong Li, Zhenggang Zhu, Yingyan Yu, Jun Yu, Jörg Tost, Paul Brennan, Ivana Holcátová, Давид Заридзе, Alvis Brāzma, Lars Egevad, Egor Prokhortchouk, Rosamonde E. Banks, Mathias Uhlén, Juris Víksna, Fredrik Ponten, Konstantin Skryabin, P. Andrew Futrea, Ewan Birney, Ake Borg, Anne Lise Børresen-Dale, Carlos Caldas, John A. Foekens, Sancha Martin, Jorge S. Reis-Filho, Andrea L. Richardson, Christos Sotiriou, Laura Van T Veer, Daniel Birnbaum, Hélène Blanché, Pascal Boucher, Sandrine Boyault, Jocelyne D. Masson-Jacquemier, Iris Pauporté, Xavier Pivot, Anne Vincent‐Salomon, Éric Tabone, Charles Theillet, Isabelle Treilleux, Paulette Bioulac‐Sage, Thomas Decaens, Franc OiseDegos, Dominique Franco, Marta Gut, Didier Samuel, Jessica Zucman‐Rossi, Roland Eils, Benedikt Brors, Jan O. Korbe, Andrey Korshunov, Pablo Landgraf, Hans Lehrach, Stefan M. Pfister, Bernhard Radlwimmer, Guido Reifenberger, Michael D. Taylor, Christof von Kalle, Partha P. Majumder, Paolo Pederzoli, Rita T. Lawlor, Massimo Delledonne, Alberto Bardelli, Thomas M. Gress, David S. Klimstra, Giuseppe Zamboni, Yusuke Nakamura, Satoru Miyano, Akihiro Fujimoto, Elı́as Campo, Silvia de Sanjosé, Emili Montserrat, Marcos González, Pedro Jares, Heinz Himmelbaue, Sı́lvia Beà, Samuel Aparício, Douglas F. Easton, Francis S. Collins, Carolyn C. Compton, Eric S. Lander, Wylie Burke, Anthony R. Green, Stanley R. Hamilton, Olli Kallioniemi, Timothy J. Ley, Edison T. Liu, Brandon J. Wainwright,

RNA modifications and cancer

Hundreds of individual human cancer genome sequences are expected to be published in 2010, and thousands per year after that. The International Cancer Genome Consortium (ICGC) was launched with the aim of keeping track of the data relating to large-scale cancer genome studies of all major cancers in adults and children — a total of 50 different cancer types and/or subtypes. In this issue the ICGC team ( http://www.icgc.org ) spells out the policies and planning for the project. The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.