Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

THE PREVALENCE OF TT VIRUS INFECTION IN RENAL TRANSPLANT RECIPIENTS IN BRAZIL

2000; Wolters Kluwer; Volume: 70; Issue: 8 Linguagem: Inglês

10.1097/00007890-200010270-00012

1534-6080

Osamu Yokosuka, Tetsu Ikeuchi, Tatsuo Kanda, S Kawai, Fumio Imazeki, Hiromitsu Saisho, Marilda Mazzalli, Gentil Alves Filho, Nancy Fusae Nishimura, Elza Cotrim Soares,

Viral Infections and Immunology Research

Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients.One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the prevalence of TTV infection. The TTV DNA in serum and its genotype were examined using polymerase chain reaction and restriction enzyme length polymorphism, respectively.TTV DNA was detected in 63/117 (53.8%) renal transplant recipients in contrast to its detection in 10/100 (10%) normal subjects (P<0.001). There was no statistical difference in the distribution of TTV genotypes between these groups. There was no significant difference in clinical backgrounds between TTV positive and negative patients.These results indicate a risk for TTV infection in renal transplant recipients in Brazil. They also indicate that TTV itself might not have a strong correlation with the pathogenicity of liver diseases.