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Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies

1985; Springer Nature; Linguagem: Inglês

10.1007/978-3-642-70644-8_21

0935-0195

H. Fraser, Patricia McBride,

Trace Elements in Health

Scrapie is a naturally occurring, lethal degeneration of the nervous system of adult sheep, caused by an unconventional, virus-like agent the nature of which has yet to be resolved. Recently, several parallels between experimental models of scrapie in mice and Alzheimer’s disease (AD) have been drawn. Each has a slowly progressing unremitting course and produces lesions confined to the CNS which are largely degenerative, with little evidence of inflammation. Some scrapie models in mice produce pathological features which are highly characteristic of AD, in particular, argyrophilic amyloid plaques and selective neuronal degeneration in the hippocampus (Bruce 1984; Bruce and Dickinson 1982; Bruce and Fraser 1975; Fraser and Bruce 1973; Hyman et al. 1984; Scott and Fraser 1984).