Portal de Periódicos da CAPES

Influence of pertussis toxin on the calcitonin‐opioid interaction in isolated tissues

1996; Wiley; Volume: 119; Issue: 5 Linguagem: Inglês

10.1111/j.1476-5381.1996.tb15743.x

1476-5381

M.I. Martı́n, Carlos Goicoechea, M.J. Ormazábal, M.J. Alfaro,

Receptor Mechanisms and Signaling

1 In order to clarify one of the mechanisms involved in the analgesic effect of calcitonin, we have tested the in vitro modifications induced by calcitonin on the effect of opioids. 2 The inhibition of the contractions induced by opioids or clonidine, in guinea-pig ileum or in mouse vas deferens, were significantly reduced in tissues incubated with pertussis toxin (PTX). When tissues were incubated with PTX and calcitonin, the inhibitory effect was restored. 3 These results suggest that calcitonin is able to potentiate a non-PTX-sensitive mechanism of transduction and support the possibility of involvement of similar G-proteins in the effects of opioid and α2-adrenoceptor agonists.