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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Human immature dental pulp stem cells share key characteristic features with limbal stem cells

2009; Wiley; Volume: 42; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2184.2009.00623.x

ISSN

1365-2184

Autores

B. G. Monteiro, R. C. Serafim, Gustavo Barreto Melo, Marcelo Cavenaghi Pereira da Silva, Nelson Foresto Lizier, C. M. C. Maranduba, Ricardo Luiz Smith, Alexandre Kerkis, H Cerruti, José Álvaro Pereira Gomes, Irina Kerkis,

Tópico(s)

Corneal surgery and disorders

Resumo

Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with either uni- or bilateral total limbal stem cells deficiency (TLSCD). Although LSC transplantation holds great promise for patients, several problems need to be overcome. In order to find an alternative source of cells that can partially substitute LSC in cornea epithelium reconstruction, we aimed at investigating whether human immature dental pulp stem cells (hIDPSC) would present similar key characteristics as LSC and whether they could be used for corneal surface reconstruction in a rabbit TLSCD model.

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