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Supraspinal Control of the Intestino‐intestinal Inhibitory Reflex

1965; Wiley; Volume: 63; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1965.tb04087.x

1365-201X

Börje Johansson, Olof Jonsson, Bengt Ljung,

Migraine and Headache Studies

Abstract Experiments were performed on chloraloseurethane‐anesthetized, vagotomized cats. Changes in the level of adrenomedullary hormones were prevented. Distension of a segment of distal jejunum produced a prompt decrease in tone and rhythmicity in the proximal jejunum. This so called intestino‐intestinal inhibition is a propriospinal reflex response apparently mediated by sympathetic efferents. Electrical stimulation in the mediocaudal part of the rhomboid fossa was found to ‘block’ this spinal intestinoinhibitory reflex. The fact that bulbar stimulation alone sometimes produced an increase in gut motility seemed to be due to suppression of a prevailing activity in the propriospinal reflex. When there was a low level of such activity medullary stimulation per se had little or no effect on intestinal motility. It is suggested that the supraspinal structures exert an inhibitory influence on impulse transmission in the propriospinal intestino‐inhibitory reflex arcs.