Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

2015; BioMed Central; Volume: 8; Issue: 1 Linguagem: Inglês

10.1186/s13071-015-0632-9

1756-3305

Jailson Brito Querido, María Gabriela Echeverría, Gerardo A. Martí, Rita Medina Costa, María Laura Susevich, Jorge Rabinovich, Aydee Copa, Nair A Montaño, Lineth García, Marisol Córdova, Faustino Torrico, Rubén Sánchez‐Eugenia, Lissete Sánchez‐Magraner, Xabier Muñiz-Trabudua, Ibai López-Marijuan, Gabriela S. Rozas-Dennis, Patricio Diosque, Ana Maria de Castro, Carlos Robello, Julio Rodriguez, Jaime Altcheh, Paz Marı́a Salazar-Schettino, Marta I Bucio, Bertha Espinoza, Diego M. A. Guérin, Marcelo Sousa Silva,

Synthesis and Biological Evaluation

Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.