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Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

2008; Cell Press; Volume: 8; Issue: 2 Linguagem: Inglês

10.1016/j.cmet.2008.06.011

1932-7420

Kevin J. Pearson, Joseph A. Baur, Kaitlyn N. Lewis, Leonid Peshkin, Nathan L. Price, Nazar Labinskyy, William R. Swindell, Davida Kamara, Robin K. Minor, Evelyn Perez, Hamish A. Jamieson, Yongqing Zhang, Stephen Dunn, Kumar Sharma, Nancy Pleshko, Laura A. Woollett, Anna Csiszár, Yuji Ikeno, David G. Le Couteur, Peter J. Elliott, Kevin G. Becker, Plácido Navas, Donald K. Ingram, Norman S. Wolf, Zoltán Ungvári, David Sinclair, Rafael de Cabo,

Adipose Tissue and Metabolism

A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.