Portal de Periódicos da CAPES

A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer

2011; Springer Nature; Volume: 3; Issue: 8 Linguagem: Inglês

10.1002/emmm.201100154

1757-4684

Fabrizio Bianchi, Francesco Nicassio, Matteo Jacopo Marzi, Elena Belloni, Valentina Dall’Olio, Loris Bernard, Giuseppe Pelosi, Patrick Maisonneuve, Giulia Veronesi, Pier Paolo Di Fiore,

Circular RNAs in diseases

Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.