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Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

2009; Oxford University Press; Volume: 24; Issue: 11 Linguagem: Inglês

10.1093/ndt/gfp302

1460-2385

Rachel Lennon, Douwe Pons, Matthew A. Sabin, Chen Wei, Julian Hamilton‐Shield, Richard J. Coward, JM Tavaré, Peter W. Mathieson, Moin A. Saleem, Gavin I. Welsh,

Chronic Kidney Disease and Diabetes

Background. Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects adipose and muscle cells. The saturated free fatty acid palmitate is elevated in insulin-resistant states and may directly contribute to cellular insulin resistance. A spectrum of renal disease is associated with increased markers of insulin resistance, although direct causal mechanisms are not known. In the kidney, glomerular podocytes are novel insulin-sensitive cells that have the ability to rapidly transport glucose. In this study, we tested the hypothesis that palmitate would induce insulin resistance in podocytes.