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A Potent Trans ‐Diimine Platinum Anticancer Complex Photoactivated by Visible Light

2010; Wiley; Volume: 49; Issue: 47 Linguagem: Inglês

10.1002/anie.201003399

1521-3773

Nicola J. Farrer, Julie A. Woods, Luca Salassa, Yao Zhao, Kim S. Robinson, Guy J. Clarkson, Fiona Mackay, Peter J. Sadler,

Metal-Catalyzed Oxygenation Mechanisms

Activating platinum with light: An inert platinum(IV) diazido complex trans, trans,trans-[Pt(N3)2(OH)2(py)2] becomes potently cytotoxic to cancer cells when activated by low doses of visible light. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.