Critical Role for Fas-Associated Death Domain-Like Interleukin-1-Converting Enzyme-Like Inhibitory Protein in Anoikis Resistance and Distant Tumor Formation
2007; Oxford University Press; Volume: 99; Issue: 10 Linguagem: Inglês
10.1093/jnci/djk182
ISSN1460-2105
AutoresImtiaz A. Mawji, Christopher D. Simpson, R. Hurren, Marcela Gronda, Michael A. Williams, Jorge Filmus, James Jonkman, R. S. Da Costa, Brian C. Wilson, Michael P. Thomas, John C. Reed, Gennadi V. Glinsky, Aaron D. Schimmer,
Tópico(s)Cancer-related Molecular Pathways
ResumoNormal epithelial cells undergo anoikis, or apoptosis on loss of anchorage to the extracellular matrix, by initiating the death receptor pathway of caspase activation. However, malignant epithelial cells with metastatic potential resist anoikis and can survive in an anchorage-independent fashion. We hypothesized that c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein (FLIP), an endogenous inhibitor of death receptor signaling, may suppress anoikis.
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