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Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain

1998; Wiley; Volume: 400; Issue: 1 Linguagem: Inglês

10.1002/(sici)1096-9861(19981012)400

1096-9861

Jiapei Dai, Dick F. Swaab, Jan van der Vliet, Ruud M. Buijs,

Photoreceptor and optogenetics research

Journal of Comparative NeurologyVolume 400, Issue 1 p. 87-102 Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain Jiapei Dai, Corresponding Author Jiapei Dai [email protected] Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsGraduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorDick F. Swaab, Dick F. Swaab Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorJan Van Der Vliet, Jan Van Der Vliet Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorRuud M. Buijs, Ruud M. Buijs Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this author Jiapei Dai, Corresponding Author Jiapei Dai [email protected] Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsGraduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorDick F. Swaab, Dick F. Swaab Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorJan Van Der Vliet, Jan Van Der Vliet Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this authorRuud M. Buijs, Ruud M. Buijs Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The NetherlandsSearch for more papers by this author First published: 06 January 1999 https://doi.org/10.1002/(SICI)1096-9861(19981012)400:1 3.0.CO;2-PCitations: 79AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The suprachiasmatic nucleus (SCN) is a small structure considered to be the site of the major circadian pacemaker of the mammalian brain. Disturbances in human biological clock function may occur in several diseases, such as Alzheimer's disease, sleep problems, and seasonal depression. Since basic knowledge of the anatomical connections of the human SCN is limited due to the lack of suitable neuroanatomical tracing methods, the understanding of physiological mechanisms of human SCN function has obviously been hampered. In the present study, the hypothalamic connections of the human SCN were revealed for the first time with a newly developed in vitro postmortem anterograde tracing method. The human SCN was found to be connected with nuclei in the hypothalamus that are involved in hormone secretion, cardiovascular regulation, and behavior activity. These human SCN projections appear to follow the same general patterns as those in the rodent brain. This homology may indicate an evolutionary conservation of the SCN projections from rodent to human. 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