Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis
2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 4 Linguagem: Inglês
10.1016/j.juro.2009.06.016
ISSN1527-3792
AutoresJoke Beuten, Dawn Garcia, Timothy C. Brand, Xin He, Ivana Balic, Edith Canby‐Hagino, Dean A. Troyer, Jacques Baillargeon, Javier Hernández, Ian M. Thompson, Robin J. Leach, Susan L. Naylor,
Tópico(s)Hippo pathway signaling and YAP/TAZ
ResumoNo AccessJournal of UrologyInvestigative Urology1 Oct 2009Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosisis companion ofTertiary Gleason Patterns and Biochemical Recurrence After Prostatectomy: Proposal for a Modified Gleason Scoring SystemLocation, Extent and Number of Positive Surgical Margins Do Not Improve Accuracy of Predicting Prostate Cancer Recurrence After Radical ProstatectomyHyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrence Joke Beuten, Dawn Garcia, Timothy C. Brand, Xin He, Ivana Balic, Edith Canby-Hagino, Dean A. Troyer, Jacques Baillargeon, Javier Hernandez, Ian M. Thompson, Robin J. Leach, and Susan L. Naylor Joke BeutenJoke Beuten Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas , Dawn GarciaDawn Garcia Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas , Timothy C. BrandTimothy C. Brand Department of Urology, University of Texas Health Science Center, San Antonio, Texas , Xin HeXin He Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas , Ivana BalicIvana Balic Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas , Edith Canby-HaginoEdith Canby-Hagino Department of Urology, University of Texas Health Science Center, San Antonio, Texas , Dean A. TroyerDean A. Troyer Department of Pathology, University of Texas Health Science Center, San Antonio, Texas , Jacques BaillargeonJacques Baillargeon Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas , Javier HernandezJavier Hernandez Department of Urology, University of Texas Health Science Center, San Antonio, Texas , Ian M. ThompsonIan M. Thompson Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas , Robin J. LeachRobin J. Leach Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas Department of Urology, University of Texas Health Science Center, San Antonio, Texas Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas , and Susan L. NaylorSusan L. Naylor Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas View All Author Informationhttps://doi.org/10.1016/j.juro.2009.06.016AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95% CI 1.12–4.04, p = 0.02 and OR 2.55, 95% CI 1.34–4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95% CI 1.20–6.12, p = 0.016 and OR 3.32, 95% CI 1.21–9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95% CI 1.06–1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men. 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Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology14 Aug 2009Tertiary Gleason Patterns and Biochemical Recurrence After Prostatectomy: Proposal for a Modified Gleason Scoring SystemJournal of Urology14 Aug 2009Location, Extent and Number of Positive Surgical Margins Do Not Improve Accuracy of Predicting Prostate Cancer Recurrence After Radical ProstatectomyJournal of Urology14 Aug 2009Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrence Volume 182Issue 4October 2009Page: 1614-1620 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsprostatic neoplasmsprostatepolymorphismsemaphorinscontinental population groupssingle nucleotideMetricsAuthor Information Joke Beuten Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Dawn Garcia Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Timothy C. Brand Department of Urology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Xin He Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Ivana Balic Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Edith Canby-Hagino Department of Urology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Dean A. Troyer Department of Pathology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Jacques Baillargeon Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas Current address: University of Texas Medical Branch, Galveston, Texas 77555. More articles by this author Javier Hernandez Department of Urology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Ian M. Thompson Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas Financial interest and/or other relationship with Veridex, Mission Pharmaceuticals and AstraZeneca. More articles by this author Robin J. Leach Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas Department of Urology, University of Texas Health Science Center, San Antonio, Texas Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas Financial interest and/or other relationship with GlaxoSmithKline. More articles by this author Susan L. Naylor Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas More articles by this author Expand All Advertisement PDF downloadLoading ...
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