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Neuronal Regulators and Vascular Dysfunction in Raynauds Phenomenon and Systemic Sclerosis

2009; Bentham Science Publishers; Volume: 7; Issue: 1 Linguagem: Inglês

10.2174/157016109787354105

1875-6212

Carmen Fonseca, David Abraham, Markella Ponticos,

Dermatologic Treatments and Research

Raynauds phenomenon (RP) results from an exaggerated cutaneous vasospastic response to cold or emotional stress. The mechanisms that lead to impaired cutaneous vascular tone are complex. The regulation of cutaneous vasoconstriction and vasodilation, involves altered sympathetic nerve activity and a host of neuronal regulators, including adrenergic and non-adrenergic, as well as REDOX signalling and other signalling such as the RhoA/ROCK pathway. This review summarises the literature concerning the regulation of vascular tone by neurohumoral factors that may be involved in RP and systemic sclerosis (SSc).