The Catalytic Asymmetric Knoevenagel Condensation
2011; Wiley; Volume: 50; Issue: 7 Linguagem: Inglês
10.1002/anie.201006319
ISSN1521-3773
AutoresAnna Lee, Anna Michrowska, Sarah Sulzer‐Mossé, Benjamin List,
Tópico(s)Chemical Synthesis and Analysis
Resumo116 years after the discovery of the Knoevenagel condensation, the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α-branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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