Portal de Periódicos da CAPES

Inhibition of Human Immunodeficiency Virus Type 1 Tat- trans -Activation-Responsive Region Interaction by an Antiviral Quinolone Derivative

2004; American Society for Microbiology; Volume: 48; Issue: 5 Linguagem: Inglês

10.1128/aac.48.5.1895-1899.2004

1098-6596

Sara N. Richter, Cristina Parolin, Barbara Gatto, Claudia Del Vecchio, Egidio Brocca‐Cofano, Arnaldo Fravolini, Giorgio Palù, Manlio Palumbo,

Cytomegalovirus and herpesvirus research

WM5, a 6-aminoquinolone derivative, binds with high affinity to the bulge of the trans-activation-responsive region (TAR), whereas it displays low binding affinity for the loop and stem regions of TAR and for random RNA and DNA sequences. Furthermore, WM5 disrupts the natural protein-nucleic acid complex with a 50% inhibitory concentration in the low micromolar range in both in vitro and in vivo assays.