Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration
2006; American Society for Microbiology; Volume: 50; Issue: 6 Linguagem: Inglês
10.1128/aac.01118-05
ISSN1098-6596
AutoresSakiko Inatsu, Ayumi Ohsaki, Kumiko Nagata,
Tópico(s)Pharmacological Effects of Natural Compounds
ResumoABSTRACT Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q 1 at low concentrations of 0.8 to 3.2 μg/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.
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