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BIBTEX RIS

Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

2009; Annual Reviews; Volume: 10; Issue: 1 Linguagem: Inglês

10.1146/annurev.genom.9.081307.164350

ISSN

1545-293X

Autores

Anand Swaroop, Emily Y. Chew, Catherine Bowes Rickman, Gonçalo R. Abecasis,

Tópico(s)

Neuroinflammation and Neurodegeneration Mechanisms

Resumo

Aging-associated neurodegenerative diseases significantly influence the quality of life of affected individuals. Genetic approaches, combined with genomic technology, have provided powerful insights into common late-onset diseases, such as age-related macular degeneration (AMD). Here, we discuss current findings on the genetics of AMD to highlight areas of rapid progress and new challenges. We also attempt to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis.

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