The Art of MicroRNA Research
2011; Lippincott Williams & Wilkins; Volume: 108; Issue: 2 Linguagem: Inglês
10.1161/circresaha.110.227496
ISSN1524-4571
Autores Tópico(s)Circular RNAs in diseases
ResumoOriginally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable techniques for measuring and modulating microRNAs in different model systems. This review summarizes experimental strategies for microRNA research and highlights the strengths and weaknesses of different approaches. The development of more specific and sensitive assays will further illuminate the biology behind microRNAs and will advance opportunities to safely pursue them as therapeutic modalities.
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