ANTI-INFLAMMATORY ACTIVITY OF PHYCOCYANIN EXTRACT IN ACETIC ACID-INDUCED COLITIS IN RATS
1999; Elsevier BV; Volume: 39; Issue: 1 Linguagem: Inglês
10.1006/phrs.1998.0409
ISSN1096-1186
AutoresRicardo González, Sandra Rodríguez, Cheyla Romay, Addys González, Julia Armesto, Diadelis Remírez, Nelsón Merino,
Tópico(s)Phytochemicals and Antioxidant Activities
ResumoThe anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats. Phycocyanin (150, 200 and 300 mg kg-1 p.o.) was administered 30 min before induction of colitis with enema of 1 ml of 4% acetic acid per rat. Twenty-four hours later myeloperoxidase (MPO) activity was determined as well as histopathological and ultrastructural studies were carried out in colonic tissue. Phycocyanin substantially reduced MPO activity which was increased in the control colitis group. Also, histopathological and ultrastructural studies showed inhibition in inflammatory cell infiltration and reduction to some extent in colonic damage in rats treated with phycocyanin. The probable role of antioxidative and the scavenging properties of phycocyanin against reactive oxygen species in the anti-colitic effect is discussed in this paper. To our knowledge this is the first report on the anti-inflammatory effect of phycocyanin in an experimental model of colitis.(c) 1999 The Italian Pharmacological Society.
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