The efficacy of methylene blue encapsulated in silica nanoparticles compared to naked methylene blue for photodynamic applications
2015; Informa; Linguagem: Inglês
10.3109/21691401.2015.1008511
ISSN2169-141X
AutoresGhaseb N. Makhadmeh, Azlan Abdul Aziz, Khairunisak Abdul Razak,
Tópico(s)Photoacoustic and Ultrasonic Imaging
ResumoBackground/Aims: This study analyzed the physical effects of methylene blue (MB) encapsulated within silica nanoparticles (SiNPs) in photodynamic therapy. Materials and methods: The optimum concentration of MB needed to destroy red blood cells (RBCs) was determined, and the efficacy of encapsulated MB-SiNPs compared to that of naked MB was verified. Results: The results confirmed the applicability of MB encapsulated in SiNPs on RBCs, and established a relationship between the concentration of the SiNP-encapsulated MB and the time required to rupture 50% of the RBCs (t50). Conclusion: The MB encapsulated in SiNPs exhibited higher efficacy compared to that of naked MB.
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